CASP1 Polyclonal Antibody

• Background :

  This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

• Description :

  This is a CASP1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  CASP-1, CASP1, CASP1, Caspase 1, Caspase-1 subunit p10, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1 beta converting enzyme, IL1B convertase, Interleukin 1 beta convertase, Interleukin 1B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting

• Swiss Prot :

  P29466, P29452, P43527

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant protein corresponding to Mouse Caspase1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1.2 mg/mL

• Dilution :

  WB 1:500-1:2000, IHC 1:300-1:800

• Buffer :

  PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  45 kDa

• Observed Molecular Weight :

  45-47 kDa,30 kDa,35 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG