S100A4 Polyclonal Antibody

• Background:

  S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.

• Description:

  This is a S100A4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  18A2,42A, calcium Placental protein, Calvasculin, CAPL, Fibroblast specific protein 1 (FSP1), Fibroblast specific protein 1, Fibroblast specific protein, FSP1, Leukemia multidrug resistance associated protein, Malignant transformation suppression 1 (MTS1), Malignan

• Swiss Prot:

  P26447, P07091, P05942

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein corresponding to Mouse S100A4

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.75 mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:300-1:800

• Buffer:

  PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  12 kDa

• Observed Molecular Weight:

  12 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG