INPP5D Polyclonal Antibody

• Background:

  This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5) -trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

• Description:

  This is a INPP5D Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Inositol polyphosphate 5 phosphatase of 145kDa,4,5-trisphosphate 5-phosphatase 1, hp51CN, Inositol polyphosphate 5 phosphatase 145kDa, Inositol polyphosphate 5 phosphatase, Inositol polyphosphate-5-phosphatase of 145 kDa, INPP5D, MGC104855, MGC142140, MGC142142, p

• Swiss Prot:

  Q9ES52, P97573

• Reactivity:

  Mouse, Rat

• Immunogen:

  KLH conjugated Synthetic peptide corresponding to Mouse SHIP1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  430 μg/mL

• Dilution:

  IHC 1:200-1:1000

• Buffer:

  PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG