Products for Research Use Only

ROCK1 Polyclonal Antibody

CAT: 0866-RD70331A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD70331A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Description
This is a ROCK1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Coiled-coil-containing protein kinase 1, coiled-coil-containing protein kinase I, MGC131603, MGC43611, p160 Rhoassociated coiled coil-forming protein kinase, p160 ROCK-1, p160 ROCK1, p160ROCK, PRO0435, Renal carcinoma antigen NY REN 35, Renal carcinoma antigen NY-R
Swiss Prot
P70335, Q63644
Reactivity
Mouse, Rat
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Rock1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
300 μg/mL
Dilution
IHC 1:100-1:400
Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG