APC Anti-Mouse CD105 Antibody

• Background:

  CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

• Description:

  This is a APC Anti-Mouse CD105 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Endoglin, END, Eng

• Gene ID:

  13805

• Swiss Prot:

  Q63961

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Conjugation:

  APC

• Type:

  Flow Cytometry Antibody

• Applications:

  FC

• Assay Type:

  Antibody

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.05% Proclin300, 1% BSA

• Storage Conditions:

  Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

• Host or Source:

  Rat

• Isotype:

  Rat IgG2a, κ