IQGAP3 Polyclonal Antibody

CAT: 0866-RD267982A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD267982A-01Size:60 μL
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Background
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Description
This is a IQGAP3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
IQGAP3
Gene ID
128239
Swiss Prot
Q86VI3
Reactivity
Human
Immunogen
Recombinant fusion protein of human IQGAP3 (NP_839943.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
184 kDa
Observed Molecular Weight
185 kDa
Host or Source
Rabbit
Isotype
IgG

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