FBXW4 Polyclonal Antibody

CAT: 0866-RD267953A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD267953A-01Size:60 μL
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Background
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Description
This is a FBXW4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
FBXW4, DAC, FBW4, FBWD4, SHFM3, SHSF3
Gene ID
6468
Swiss Prot
P57775
Reactivity
Mouse
Immunogen
Recombinant fusion protein of human FBXW4 (NP_071322.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
46 kDa
Observed Molecular Weight
46 kDa
Host or Source
Rabbit
Isotype
IgG

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