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CLOCK Polyclonal Antibody

CAT: 0866-RD267691A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD267691A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
Description
This is a CLOCK Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CLOCK, KAT13D, bHLHe8
Gene ID
9575
Swiss Prot
O15516
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CLOCK (NP_004889.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
95 kDa
Observed Molecular Weight
110 kDa
Host or Source
Rabbit
Isotype
IgG

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