CLOCK Polyclonal Antibody

• Background:

  The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

• Description:

  This is a CLOCK Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  CLOCK, KAT13D, bHLHe8

• Gene ID:

  9575

• Swiss Prot:

  O15516

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human CLOCK (NP_004889.1) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  95 kDa

• Observed Molecular Weight:

  110 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG