TYROBP Polyclonal Antibody

CAT: 0866-RD267654A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD267654A-01Size:60 μL
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Background
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
Description
This is a TYROBP Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
TYROBP, DAP12, KARAP, PLOSL
Gene ID
7305
Swiss Prot
O43914
Reactivity
Mouse, Rat
Immunogen
Recombinant fusion protein of human TYROBP (NP_003323.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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