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DUT Polyclonal Antibody

CAT: 0866-RD267503A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD267503A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Description
This is a DUT Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
DUT, dUTPase
Gene ID
1854
Swiss Prot
P33316
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human DUT (NP_001020419.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000 IHC 1:50-1:200 IF 1:100-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
17 kDa/26 kDa
Observed Molecular Weight
24 kDa
Host or Source
Rabbit
Isotype
IgG

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