NUAK1 Polyclonal Antibody

CAT: 0866-RD267108A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD267108A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5 (ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Description
This is a NUAK1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
NUAK1, ARK5
Gene ID
9891
Swiss Prot
O60285
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein of human NUAK1 (NP_055655.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:200-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
23 kDa/74 kDa
Observed Molecular Weight
74 kDa
Host or Source
Rabbit
Isotype
IgG

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