MLKL Polyclonal Antibody

CAT: 0866-RD267102A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD267102A-01Size:60 μL
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Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Description
This is a MLKL Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
HMLKL, MLKL
Gene ID
197259
Swiss Prot
Q9D2Y4
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of mouse MLKL
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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