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COL18A1 Polyclonal Antibody

CAT: 0866-RD267082A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD267082A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.
Description
This is a COL18A1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
COL18A1, KNO, KNO1, KS
Gene ID
80781
Swiss Prot
P39060
Reactivity
Mouse
Immunogen
A synthetic peptide of human COL18A1 (NP_085059.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
135 kDa/154 kDa/178 kDa
Observed Molecular Weight
240 kDa
Host or Source
Rabbit
Isotype
IgG

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