DNMT1 Polyclonal Antibody

• Background:

  This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

• Description:

  This is a DNMT1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNMT1

• Gene ID:

  1786

• Swiss Prot:

  P26358

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human DNMT1.

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IHC 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  144 kDa/183 kDa/184 kDa

• Observed Molecular Weight:

  230 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG