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CAB39 Polyclonal Antibody

CAT: 0866-RD266698A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD266698A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha) . STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK) .
Description
This is a CAB39 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CAB39, CGI-66, MO25
Gene ID
51719
Swiss Prot
Q9Y376
Reactivity
Human
Immunogen
A synthetic peptide of human CAB39 (NP_001124321.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
39 kDa
Observed Molecular Weight
35 kDa
Host or Source
Rabbit
Isotype
IgG

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