CAB39 Polyclonal Antibody

• Background :

  Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha) . STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK) .

• Description :

  This is a CAB39 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  CAB39, CGI-66, MO25

• Gene ID :

  51719

• Swiss Prot :

  Q9Y376

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide of human CAB39 (NP_001124321.1) .

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  39 kDa

• Observed Molecular Weight :

  35 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG