HLA-DPB1 Polyclonal Antibody

HLA-DPB1 Polyclonal Antibody

• Background: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
• Synonyms: DPB1,HLA-DP,HLA-DP1B,HLA-DPB,HLA-DPB1,major histocompatibility complex,class II,DP beta 1
• CAS Number: 9007-83-4
• Gene ID: 3115
• Swiss Prot: P04440
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Immunogen: Recombinant fusion protein of human HLA-DPB1 (NP_002112.3).
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: IHC
• Purification: Affinity purification
• Concentration: 1 mg/mL
• Dilution: IHC 1:50-1:200
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.