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MLKL Polyclonal Antibody

CAT: 0866-RD266077A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD266077A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Description
This is a MLKL Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
MLKL, hMLKL
Gene ID
74568
Swiss Prot
Q9D2Y4
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of mouse MLKL (NP_001297542.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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