RAG2 Polyclonal Antibody

• Background :

  This gene encodes a protein that is involved in the initiation of V (D) J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

• Description :

  This is a RAG2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  RAG2, RAG-2

• Gene ID :

  5897

• Swiss Prot :

  P55895

• Reactivity :

  Mouse

• Immunogen :

  Recombinant fusion protein of human RAG2 (NP_001230715.1) .

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  59 kDa

• Observed Molecular Weight :

  59 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG