Products for Research Use Only

RAG2 Polyclonal Antibody

CAT: 0866-RD265916A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD265916A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein that is involved in the initiation of V (D) J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Description
This is a RAG2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
RAG2, RAG-2
Gene ID
5897
Swiss Prot
P55895
Reactivity
Mouse
Immunogen
Recombinant fusion protein of human RAG2 (NP_001230715.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
59 kDa
Observed Molecular Weight
59 kDa
Host or Source
Rabbit
Isotype
IgG