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SMAD7 Polyclonal Antibody

CAT: 0866-RD265776A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD265776A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3) . Several transcript variants encoding different isoforms have been found for this gene.
Description
This is a SMAD7 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
SMAD7, CRCS3, MADH7, MADH8
Gene ID
4092
Swiss Prot
O15105
Reactivity
Human
Immunogen
Recombinant fusion protein of human SMAD7 (NP_005895.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000 IF 1:50-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
23 kDa/46 kDa
Observed Molecular Weight
46 kDa
Host or Source
Rabbit
Isotype
IgG

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