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VHL Polyclonal Antibody

CAT: 0866-RD265684A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD265684A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Description
This is a VHL Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
VHL, HRCA1, RCA1, VHL1, pVHL, PVHL
Gene ID
7428
Swiss Prot
P40337
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human VHL (NP_937799.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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