PFKFB3 Polyclonal Antibody

• Background :

  The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Description :

  This is a PFKFB3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  Renal Carcinoma Antigen NY-REN-56, PFK/FBPase 3, IPFK2, PFK2

• Swiss Prot :

  Q16875

• Accession Number :

  NP004557

• Reactivity :

  Human, Rat

• Immunogen :

  Synthetic peptide of human PFKFB3

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, ELISA

• Purification Method :

  Antigen affinity purification

• Assay Type :

  Antibody

• Concentration :

  0.5 mg/mL

• Dilution :

  WB 1:500-1:2000, ELISA 1:5000-1:10000

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  60 kDa

• Observed Molecular Weight :

  Refer to figures

• Host or Source :

  Rabbit

• Isotype :

  IgG