MAFA Polyclonal Antibody

• Background:

  Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity.

• Description:

  This is a MAFA Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  HMafA, Mafa, MAFA, Pancreatic beta cell specific transcriptional activator, Pancreatic beta-cell-specific transcriptional activator, RIPE3b1, Transcription factor MafA, Transcription factor RIPE3b1, v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)

• Swiss Prot:

  Q8NHW3

• Accession Number:

  NP963883

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide of human MAFA

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, ELISA

• Purification Method:

  Antigen affinity purification

• Assay Type:

  Antibody

• Concentration:

  1.2 mg/mL

• Dilution:

  WB 1:500-1:2000, ELISA 1:5000-1:10000

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  37 kDa

• Observed Molecular Weight:

  Refer to figures

• Host or Source:

  Rabbit

• Isotype:

  IgG