HRAS Polyclonal Antibody

• Background:

  This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

• Description:

  This is a HRAS Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  C BAS/HAS, c H ras, C HA RAS1, c has/bas p21 protein, c ras Ki 2 activated oncogene, c-H-ras, CTLO, GTP and GDP binding peptide B, GTPase HRas, N-terminally processed, H Ras 1, H RASIDX, H-Ras-1, Ha Ras, Ha Ras1 proto oncoprotein, Ha-Ras, HAMSV, Harvey rat sarcoma viral o

• Swiss Prot:

  P01112

• Accession Number:

  NP001123914

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide of human HRAS

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, ELISA

• Purification Method:

  Antigen affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.66 mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:25-1:50, ELISA 1:5000-1:10000

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  21 kDa

• Observed Molecular Weight:

  Refer to figures

• Host or Source:

  Rabbit

• Isotype:

  IgG