CBFA2T2 Polyclonal Antibody

• Background:

  In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

• Description:

  This is a CBFA2T2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  AML1 MTG8, cbfa2t2, Core binding factor runt domain alpha subunit 2 translocated to 2, core-binding factor, runt domain, alpha subunit 2, DKFZp313F2116, EHT, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG 8 like protein, MTG 8 related protein 1

• Swiss Prot:

  O43439

• Accession Number:

  BC040344

• Reactivity:

  Human, Mouse

• Immunogen:

  Fusion protein of human CBFA2T2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC, ELISA

• Purification Method:

  Antigen affinity purification

• Assay Type:

  Antibody

• Concentration:

  1.08 mg/mL

• Dilution:

  IHC 1:50-1:300, ELISA 1:5000-1:10000

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG