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PNRC2 Polyclonal Antibody

CAT: 0866-RD252809A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD252809A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429) . May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429) . Required for UPF1/RENT1 localization to the P-body (PubMed:19150429) . Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514) . Also acts as a nuclear receptor coactivator (PubMed:11574675) . May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity) .
Description
This is a PNRC2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
0610011E17Rik, D4Bwg0593e, FLJ20312, MGC11707, MGC93828, MGC99541, OTTMUSP00000010360, OTTMUSP00000010366, pnrc2, PNRC2, Proline rich nuclear receptor coactivator 2, Proline-rich nuclear receptor coactivator 2, RP11-4M23.5, RP23-161N17.3
Swiss Prot
Q9NPJ4
Accession Number
BC001959
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human PNRC2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.84 mg/mL
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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