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LIG4 Polyclonal Antibody

CAT: 0866-RD252776A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD252776A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V (D) J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ) . This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK) . Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
Description
This is a LIG4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
DNA ligase IV ATP dependent, DNA joinase, DNA ligase 4, DNA ligase IV, DNA repair enzyme, DNLI4, LIG 4, LIG4, LIG4S, Ligase IV, Ligase IV DNA ATP dependent, Polydeoxyribonucleotide synthase [ATP] 4, Polydeoxyribonucleotide synthase 4, Polydeoxyribonucleotide synthase
Swiss Prot
P49917
Accession Number
BC037491
Reactivity
Human, Mouse
Immunogen
Fusion protein of human LIG4
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.08 mg/mL
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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