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NGEF Polyclonal Antibody

CAT: 0866-RD252771A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD252771A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) .
Description
This is a NGEF Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ARHGEF27, Eph receptor-interacting exchange protein, Eph-interacting exchange protein, EPHEXIN, Ephexin-1, Guanine nucleotide exchange factor, neuronal, Neuronal guanine nucleotide exchange factor, Ngef, NGEF
Swiss Prot
Q8N5V2
Accession Number
BC031573
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human NGEF
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.6 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
82 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG

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