RYR2 Polyclonal Antibody

• Background:

  This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.RYR2 (Ryanodine Receptor 2) is a Protein Coding gene. Diseases associated with RYR2 include Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 and Arrhythmogenic Right Ventricular Dysplasia 2. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell-type Dependent Selectivity of CCK2R Signaling. GO annotations related to this gene include calcium ion binding and protein kinase binding. An important paralog of this gene is RYR3.

• Description:

  This is a RYR2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  ARVC2, ARVD2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, hRYR-2, ryanodine receptor 2 (cardiac), Ryanodine receptor 2, RyR, RYR-2, RyR2, RYR2, Type 2 ryanodine receptor, VTSIP

• Swiss Prot:

  Q92736

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human RyR-2 around the non-phosphorylation site of Ser2808.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC-p, IF, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

• Buffer:

  PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  564 kDa

• Observed Molecular Weight:

  200-300 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG