Purified Anti-Human CD279/PD-1 Antibody

• Background:

  Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

• Description:

  This is a Purified Anti-Human CD279/PD-1 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  PDCD1, PD1, Protein PD-1, hPD-1

• Gene ID:

  3683

• Swiss Prot:

  Q15116

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Flow Cytometry Antibody

• Applications:

  FC

• Assay Type:

  Antibody

• Concentration:

  0.5 mg/mL

• Buffer:

  PBS with 0.05% Proclin300

• Storage Conditions:

  Store at 2~8°C. Do not freeze.

• Host or Source:

  Mouse

• Isotype:

  Mouse IgG1, κ