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PLN Polyclonal Antibody

CAT: 0866-RD219885A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD219885A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+) -ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Description
This is a PLN Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Cardiac phospholamban, CMD1P, CMH18, PLB, Pln, PPLA
Swiss Prot
P26678
Accession Number
NP002658
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human PLN
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.26 mg/mL
Dilution
IHC 1:50-1:100, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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