CEND1 Polyclonal Antibody

• Background :

  BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

• Description :

  This is a CEND1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  BM88 , BM88 antigen, Cell cycle exit and neuronal differentiation 1 , Cell cycle exit and neuronal differentiation protein 1, FLJ90066, MGC34326

• Swiss Prot :

  Q8N111

• Accession Number :

  NP057648

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide of human CEND1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC, ELISA

• Purification Method :

  Antigen affinity purification

• Assay Type :

  Antibody

• Concentration :

  0.9 mg/mL

• Dilution :

  WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  15 kDa

• Observed Molecular Weight :

  Refer to figures

• Host or Source :

  Rabbit

• Isotype :

  IgG