CD274 Polyclonal Antibody

CAT: 0866-RD219627A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD219627A-01Size:20 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation .
Description
This is a CD274 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
B7 H, B7 H1, B7 homolog 1, B7-H1, B7H, B7H1, CD 274, CD274, CD274 antigen, CD274 molecule, MGC142294, MGC142296, OTTHUMP00000021029, PD L1, PD-L1, PD1L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL 1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, RGD1566211
Swiss Prot
Q9NZQ7
Accession Number
NP054862
Reactivity
Human
Immunogen
Synthetic peptide of human CD274
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.72 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
33 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG

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