RBL2 Polyclonal Antibody

CAT: 0866-RD219324A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD219324A-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Description
This is a RBL2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
130 kDa retinoblastoma associated protein,130 kDa retinoblastoma-associated protein, IB4, p130, PPAR-alpha-interacting complex protein 128, PRB2, Rb2, Rbl2, RBL2, RBR 2, RBR-2, RBR2, Retinoblastoma like 2, Retinoblastoma-like protein 2, Retinoblastoma-related protein
Swiss Prot
Q08999
Accession Number
NP005602
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human RBL2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.8 mg/mL
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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