CUL4A Polyclonal Antibody

• Background :

  Cullin proteins assemble a large number of RING E3 ubiquitin ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B (104 kDa), have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases, DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol, suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2.

• Description :

  This is a CUL4A Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  2810470J21Rik, AW495282, CUL 4A, CUL-4A, Cul4a, Cul4a protein, CUL4A, Cullin-4A, MGC36573, MGC64071

• Swiss Prot :

  Q13619

• Accession Number :

  NP001008895

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthetic peptide of human CUL4A

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB, IHC, ELISA

• Purification Method :

  Antigen affinity purification

• Assay Type :

  Antibody

• Concentration :

  1.62 mg/mL

• Dilution :

  WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  88 kDa

• Observed Molecular Weight :

  Refer to figures

• Host or Source :

  Rabbit

• Isotype :

  IgG