AF/LE Purified Anti-Mouse CD103 Antibody

• Background:

  CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

• Synonyms:

  Integrin alpha-E,Itgae,Integrin alpha M290,CD103

• Gene ID:

  16407

• Swiss Prot:

  Q60677

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Conjugation:

  None (Purified antibody-Azide Free/Low endotoxin)

• Applications:

  FCM,Block

• Concentration:

  0.5 mg/mL

• Buffer:

  0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

• Storage Conditions:

  Store at 2~8°C. Do not freeze.

• CAS Number:

  9007-83-4