Anti-DDR1 Antibody

Anti-DDR1 Antibody

• Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
• Description: Boster Bio Anti-DDR1 Antibody (Catalog # M00905-1). Tested in WB, IHC-P application(s). This antibody reacts with Human.
• Synonyms: Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK
• Gene Name: DDR1
• UniProt: Q08345
• Host: Mouse
• Reactivity: Human
• Immunogen: This DDR1 antibody is generated from a mouse immunized with a recombinant protein.
• Clonality: Monoclonal
• Applications: WB, IHC-P
• Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
• Molecular Weight: 101128 Da
• Components: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Fragment: IgG2b, k
• Clone ID: Clone: 1464CT339.1.54