Anti-UBE2L6 Antibody (N-term)

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) . UBE2L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to function in the E6/E6-ap-induced ubiquitination of p53.

• Description:

  Boster Bio Anti-UBE2L6 Antibody (N-term) (Catalog # A07315-1) . Tested in WB, IHC-P application (s) . This antibody reacts with Human.

• Synonyms:

  Ubiquitin/ISG15-conjugating enzyme E2 L6, Retinoic acid-induced gene B protein, RIG-B, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, UBE2L6, UBCH8

• Gene Name:

  UBE2L6

• UniProt:

  O14933

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UBE2L6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human UBE2L6.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Present in natural killer cells (at protein level) .

• Applications:

  WB, IHC-P

• Field of Research:

  Cell Biology

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

• Molecular Weight:

  17769 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG