Anti-beta Tubulin

• Background:

  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

• Description:

  Boster Bio Anti-beta Tubulin (Catalog # M32657) . Tested in WB, Flow Cytometry, IF application (s) . This antibody reacts with Mouse, Rat.

• Synonyms:

  Tubulin beta-5 chain, Tubb5

• Gene Name:

  Tubb5

• UniProt:

  P99024

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Immunogen:

  This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 46-78 amino acids from human.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Expressed in embryonic brain, including throughout the developing cortex and in the subventricular zone. Also found in radial glial cells, intermediate progenitors, migrating neurons and postmitotic neurons (PubMed:23246003) . Expressed in skin and developing hair follicle (PubMed:26637975)

• Applications:

  WB, Flow Cytometry, IF

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

• Molecular Weight:

  49671 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Cytoplasm, cytoskeleton

• Prediction Reactivity:

  C. elegans, Chicken, Drosophila, Human, Monkey, Bovine, Xenopus, Hamster, Pig