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Anti-MKRN2 Antibody

CAT: 0519-M10562-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M10562-01Size:50 µL
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Background
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Description
Boster Bio Anti-MKRN2 Antibody (Catalog # M10562) . Tested in WB, Flow Cytometry, IHC-P, IF application (s) . This antibody reacts with Human.
Synonyms
Probable E3 ubiquitin-protein ligase makorin-2, 632-, RING finger protein 62, MKRN2, RNF62
Gene Name
MKRN2
UniProt
Q9H000
Host
Mouse
Reactivity
Human
Immunogen
This MKRN2 antibody is generated from a mouse immunized with recombinant protein.
Clonality
Monoclonal
Clone
Clone: 1556CT631.230.55.49
Tissue Specificity
Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940) . Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen (PubMed:11597136) .
Applications
WB, Flow Cytometry, IHC-P, IF
Field of Research
Cell Biology, Neuroscience
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) . Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity) . Plays a role in the regulation of spermiation and in male fertility (By similarity) .
Molecular Weight
46940 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, k
Subcellular Location
Cytoplasm {ECO:0000250|UniProtKB:Q9ERV1}. Nucleus {ECO:0000250|UniProtKB:Q9ERV1}

UniProtKB · Q9H000

E3 ubiquitin-protein ligase makorin-2

MKRN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H000
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MKRN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A6NIA2, B3KRC5, B4DPR4, Q8N391, Q96BD4, Q9BUY2, Q9NRY1
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

DifferentiationSpermatogenesisUbl conjugation pathway

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger

Molecular function

Transferase

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