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Anti-PSMC2 Antibody

CAT: 0519-M09306-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M09306-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.
Description
Boster Bio Anti-PSMC2 Antibody (Catalog # M09306) . Tested in WB application (s) . This antibody reacts with Human.
Synonyms
26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1
Gene Name
PSMC2
UniProt
P35998
Host
Mouse
Reactivity
Human
Immunogen
This antibody is generated from a mouse immunized with a recombinant protein from human.
Clonality
Monoclonal
Clone
Clone: 1851CT193.4.40
Applications
WB
Field of Research
Cell Biology, Signal Transduction, Viral process, Host-Virus Interaction, Proteasome
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:2000
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Molecular Weight
48634 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, k
Subcellular Location
Cytoplasm. Note=Colocalizes with TRIM5 in cytoplasmic bodies
Prediction Reactivity
Bovine, Monkey, Mouse

UniProtKB · P35998

26S proteasome regulatory subunit 7

PRS7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35998
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PSMC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A4D0Q1, B7Z5E2, Q3LIA5, Q9UDI3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmProteasome

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