Anti-RAB1B Antibody

• Background:

  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.

• Description:

  Boster Bio Anti-RAB1B Antibody (Catalog # M04589-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Ras-related protein Rab-1B, RAB1B

• Gene Name:

  RAB1B

• UniProt:

  Q9H0U4

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This RAB1B antibody is generated from a mouse immunized with a recombinant protein between 1-201 amino acids from human RAB1B.

• Clonality:

  Monoclonal

• Clone:

  Clone: 1673CT571.17.71

• Applications:

  WB

• Field of Research:

  Signal Transduction, Autophagy

• Purification:

  This antibody is purified through a protein G column, followed by dialysis against PBS.

• Dilution:

  WB: 1:4000

• Function:

  20545908943700294370022054590826209634

• Molecular Weight:

  22171 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  IgG1, k

• Subcellular Location:

  Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P10536}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151) . In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151) . Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity) . {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:11389151}