Anti-SLC22A2 Antibody (N-term)

• Background:

  Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino) -styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

• Description:

  Boster Bio Anti-SLC22A2 Antibody (N-term) (Catalog # M01612) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human.

• Synonyms:

  Solute carrier family 22 member 2, Organic cation transporter 2, hOCT2, SLC22A2, OCT2

• Gene Name:

  SLC22A2

• UniProt:

  O15244

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SLC22A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 57-89 amino acids from the N-terminal region of human SLC22A2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Mainly expressed in kidney, in the cortex and medulla (PubMed:9260930, PubMed:12089365, PubMed:11912245) . Localized in testis, mostly to peritubular myoid cells and Leydig cells and also detected along the basal membrane of Sertoli cells (PubMed:12089365, PubMed:35307651) . Expressed in brain, in neurons of the cerebral cortex and in various subcortical nuclei (PubMed:9260930, PubMed:12089365, PubMed:9687576) . In the brain, also detected in the dopaminergic regions of the substantia nigra (PubMed:17460754) . Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714) . Also detected in secretory phase endometrium, in scattered stromal cells (PubMed:17393420) . Expressed in spleen, placenta, small intestine and spinal cord (PubMed:9260930, PubMed:12089365) . Weakly expressed in prostate, uterus and lung (PubMed:12089365) .

• Applications:

  WB, IHC-P, Flow Cytometry

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  9260930968757696875762112859892609309687576152121621578307396875761658109317460754174607541581771492609301208936515212162170720982496137392609301253883721128598119071861239528816394027

• Molecular Weight:

  62581 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R0W2}; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651) . Localized to the basolateral membrane of proximal tubule (PubMed:11912245) . Localized to the luminal/apical membrane of distal tubule (PubMed:9260930) . Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714) .