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Anti-NR3C1

CAT: 0519-M00503-2-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M00503-2-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
27120390959069625775514
Description
Boster Bio Anti-NR3C1 (Catalog # M00503-2) . Tested in WB application (s) . This antibody reacts with Human, Mouse.
Synonyms
Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Gene Name
NR3C1
UniProt
P04150
Host
Mouse
Reactivity
Human, Mouse
Immunogen
This antibody is generated from a mouse immunized with a recombinant protein from human.
Clonality
Monoclonal
Clone
Clone: 2153CT307.32.80
Tissue Specificity
Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991) . In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803) [Isoform Alpha-2]: Widely expressed.
Applications
WB
Field of Research
Cancer, Signal Transduction, Mitochondria
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:2000
Function
2712039028139699959069625775514
Molecular Weight
85659 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, κ
Subcellular Location
[Isoform Alpha]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity) . Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity) . {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628} [Isoform Alpha-B]: Nucleus. Cytoplasm Note=After ligand activation, translocates from the cytoplasm to the nucleus.
Prediction Reactivity
Human, Mouse

UniProtKB · P04150

Glucocorticoid receptor

GCR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04150
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NR3C1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GR
EC number
—
Processing
—
Secondary accessions
A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04151, Q53EP5, Q6N0A4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative initiationAlternative splicing

Biological process

ApoptosisCell cycleCell divisionChromosome partitionMitosisTranscriptionTranscription regulation

Molecular function

Chromatin regulatorDNA-bindingReceptorRNA-binding

Cellular component

ChromosomeCytoplasmCytoskeletonMitochondrionNucleus

Disease

Disease variantPseudohermaphroditism

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Domain

Zinc-finger

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