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Anti-TLR2 Antibody

CAT: 0519-M00131-1-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M00131-1-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Description
Boster Bio Anti-TLR2 Antibody (Catalog # M00131-1) . Tested in WB application (s) . This antibody reacts with Human.
Synonyms
Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4
Gene Name
TLR2
UniProt
O60603
Host
Mouse
Reactivity
Human
Immunogen
This TLR2 Antibody is generated from a mouse immunized with a recombinant protein .
Clonality
Monoclonal
Clone
Clone: 1070CT4.2.3.2
Tissue Specificity
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues
Applications
WB
Field of Research
Cardiovascular, Immunology, Microbiology, Signal Transduction, Inflammation, Innate Immunity, TLR Signaling
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:500-1:1000
Function
21078852178896511042699510426996114411071662220516622205193627121580930316880211
Molecular Weight
89838 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, κ
Subcellular Location
Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.

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