Anti-human CD71 TFRC Monoclonal Antibody FITC Conjugated, Flow Validated

• Background:

  CD71 is also known as transferrin receptor (TFRC) . Nikinmaa and Schroder (1987) concluded that p90 and TFRC are the same protein: studies using monoclonal antibodies indicated that exhaustive precipitation of radioactively labeled lysates with one antibody removed all activity of lysates with the other. Peptide maps of antigens recognized with both antibodies showed great similarity and indicated that both antibodies react with the same antigen, the human transferrin receptor, but with different antigenic sites of the molecule.TFR is assigned to chromosome 3.

• Description:

  Boster Bio Anti-human CD71 TFRC Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC00591-FITC) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

• Synonyms:

  Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1, serum form; sTfR; TFRC

• Gene Name:

  TFRC

• UniProt:

  P02786

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human acute lymphoblastic leukaemia cells

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: OKT9

• Conjugation:

  FITC

• Applications:

  Flow Cytometry

• Field of Research:

  Cancer, Cancer Metabolism, Cardiovascular, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Metabolism, Metabolism Processes, Myeloid, Neural Stem Cells, Pathways and Processes, Response To Hypoxia, Serum Proteins, Stem Cells, Surface Molecules, T Lymphocytic Lineage

• Purification:

  Protein A purified

• Sensitivity:

  5ul per sample

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Dilution:

  User needs to optimize the dilution ratio for this antibody.

• Form:

  Liquid

• Function:

  Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. .

• Molecular Weight:

  84871 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 2-8°C. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG1, k

• Other Gene Names:

  Transferrin receptor protein 1

• Subcellular Location:

  Cell membrane; Single-pass type II membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

• Protein Name:

  Transferrin receptor protein 1