MIA2 Melanoma Inhibitory Activity 2 Human Recombinant Protein

• Description:

  MIA2 Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain consisting of 101 amino having a total molecular mass of 11.5 kDa. The MIA2 is purified by proprietary chromatographic techniques.

• Synonyms:

  MIA-2; MIA2; Melanoma Inhibitory Activity 2; FLJ22404

• Gene Name:

  MIA2

• UniProt:

  Q96PC5

• Reactivity:

  Human

• Tissue Specificity:

  Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis (PubMed:12586826) . Isoform 1 is specifically expressed in lung, testis, small intestine, colon, pancreas, kidney, liver and prostate (PubMed:27138255) .

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 97.0% as determined by (a) Analysis by RP-HPLC and (b) Analysis by SDS-PAGE.

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  It is recommended to reconstitute the lyophilized MIA2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

• Function:

  Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255) . Thereby, may play a role in cholesterol and triglyceride homoestasis (By similarity) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized MIA2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIA2 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

• Other Gene Names:

  Melanoma inhibitory activity protein 2

• Subcellular Location:

  Isoform 1: Endoplasmic reticulum membrane