BMP13 Bone Morphogenetic protein-13 Human Recombinant Protein

• Description:

  BMP13 Human Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 120 amino acids and having a molecular mass of 27.1kDa. The BMP-13 is purified by proprietary chromatographic techniques.

• Synonyms:

  Growth Differentiation Factor 6; Growth/Differentiation Factor 16; Bone Morphogenetic Protein 13; BMP-13; BMP13; GDF-6; Klippel-Feil Malformation; Segmentation Syndrome 1; Klip-Feil Malformation; Klippel-Feil Syndrome; MCOPCB6; SCDO4; CDMP2; LCA17; MCOP4; GDF16; KFS1; KFSL; SGM1; KFM; KFS; GDF6

• Gene Name:

  GDF6

• UniProt:

  Q6KF10

• Reactivity:

  Human

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 95.0% as determined by (a) Analysis by HPLC. (b) Analysis by SDS-PAGE.

• Bioactivity:

  50

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  2

• Function:

  Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924) . Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732) . Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized BMP13 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-13 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Other Gene Names:

  Growth/differentiation factor 6

• Subcellular Location:

  Secreted