Noggin Mouse Recombinant Protein

• Description:

  Noggin Mouse Recombinant produced in E. coli is a non-glycosylated, disulfide-linked protein consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 46.4 kDa (each chain 23.2 kDa) .

• Synonyms:

  Noggin; SYM1; SYNS1; NOG

• Gene Name:

  NOG

• UniProt:

  P97466

• Reactivity:

  Mouse

• Tissue Specificity:

  Expressed in condensing cartilage and immature chondrocytes.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 95.0% as determined by SDS-PAGE.

• Bioactivity:

  505

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  It is recommended to be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

• Function:

  Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (PubMed:9585504, PubMed:9603738) . Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized Mouse Noggin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse Noggin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Please prevent freeze-thaw cycles.

• Other Gene Names:

  Noggin

• Subcellular Location:

  Secreted.