MIF Macrophage Migration Inhibitory Factor Rat Recombinant Protein

• Description:

  MIF Rat Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 12.5kDa. The MIF is purified by proprietary chromatographic techniques.

• Synonyms:

  Macrophage migration inhibitory factor; MIF; Glutathione-binding 13 kDa protein; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase

• Gene Name:

  MIF

• UniProt:

  P30904

• Reactivity:

  Rat

• Tissue Specificity:

  Expressed in a wide variety of organs including brain, spleen, liver, muscle and kidney.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 95.0% as determined by (a) Analysis by RP-HPLC and (b) Analysis by SDS-PAGE.

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  2

• Function:

  Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized MIF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Other Gene Names:

  Macrophage migration inhibitory factor

• Subcellular Location:

  Secreted