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SP100 Recombinant Protein Human

CAT: 0519-PROTP23497-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0519-PROTP23497-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recombinant Sp100 antigen is a full-length cDNA coding having a molecular mass of 54,662 Dalton (pH 5.0) .Shows a 79kDa band on SDS-PAGE. Sp100 protein is fused to a hexa-histidine purification tag. Applications: Western blot with PBC sera or monoclonal anti-hexa-His-tag antibody.
Synonyms
Nuclear dot-associated Sp100 protein; SP100 nuclear antigen; Speckled 100 kDa; SP100-HMG nuclear autoantigen; FLJ00340; Lysp100b
Gene Name
SP100
UniProt
P23497
Tissue Specificity
Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
Source
Sf9 insect cells
Applications
WB
Purification
Greater than 80% as determined by SDS-PAGE.
Function
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
Shipping Conditions
Available
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Other Gene Names
Nuclear autoantigen Sp-100
Subcellular Location
Nucleus. Nucleus, PML body. Cytoplasm. Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon- dependent. Accumulates in the cytoplasm upon FAS activation.

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